What’s the buzz?: Synthetic marijuana, K2, Spice, JWH-018

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My field of natural products pharmacology was founded by indigenous cultures who recognized that plants and fungi contain compounds that produce altered states of consciousness, leading to their most common use in religious ceremonies. While we may most often associate these naturally-occurring drugs with hallucinogens, the arguably most common natural product in use today is marijuana or Cannabis sativa. Indigenous to India and China, Cannabis has been the subject of increasing decriminalization worldwide due in part to its clinical, medicinal effects in multiple sclerosis, cancer, and AIDS.
K2 assortment.jpg

Over the last few months, I’ve seen reports of a so-called “synthetic marijuana” being sold on the internet with stories most commonly coming from England and Germany and, in the US, from Kansas, Missouri, and Arizona. In fact, the St. Louis Post-Dispatch reports today that a bill has been brought before the Missouri House Public Safety Committee seeking to add this product to the state’s list of illegal drugs.

I became intrigued as to why anyone would go through the trouble of making a synthetic marijuana when the real thing is so readily cultivated worldwide, albeit illegally in most locales.

So what is it?

“Fake weed”
Synthetic marijuana, marketed as K2 or Spice, is an herbal substance sold as an incense or smoking material that remains legal in the United States. The products contain one or more synthetic compounds that behave similarly to the primary psychoactive constituent of marijuana, &Delta9-tetrahydrocannabinol or THC.

The compound most commonly found in these products is a chemical first synthesized by the well-known Clemson University organic chemist, Prof John W Huffman: the eponymous JWH-018. Another compound, found in Spice products sold in Germany, is an analog of CP-47,497, a cannabinoid developed by Pfizer over 20 years ago.
Known as (1-pentyl-3-(1-naphthoyl)indole), or the more proper IUPAC name of Naphthalen-1-yl-(1-pentylindol-3-yl)methanone, JWH-018 is one of over 100 indoles, pyrroles, and indenes synthesized by the Huffman laboratory to develop cannabimimetics, drugs that mimic the effect of cannabinoids such as THC. The primary goal of these studies was to create pharmacological probes to 1) determine the structure-activity relationships of these compounds and 2) tease out the physiological function of subtypes of receptors we have for cannabinoids: the CB1 and CB2 receptors.

What does it do?
Much of the biological assessment work of Dr. Huffman’s compounds was carried out by the laboratory of Professor Billy R. Martin of the Medical College of Virginia. Dr. Martin, a native of North Carolina, was a giant in the field and sadly left us two summers ago at the all-too-young age of 65 (obituary).

According to this 2000 paper in Drug and Alcohol Dependence from the Huffman and Martin groups, JWH-018 binds to the psychotropic CB1 receptor with approximately 4 times the potency of the naturally-occurring THC. Unlike THC, which binds with almost equal affinity to CB1 and CB2 receptors, JWH-018 exhibits a 3-fold preference for CB1 receptors.

What does this mean? Well, the CB1 receptor is the primary means by which cannabinoids exert their psychotropic effects. The CB2 receptor, on the other hand, appears to be more involved in pain and inflammation and is therefore a very active area of research for new therapeutics.

So while JWH-018 has four-fold greater potency for CB1 receptors than THC in an isolated receptor binding study, how its effect compares to plain-old marijuana depends on other factors such as the relative amount in the product, how stable it is to combustion, how it’s metabolized in the body, among others.

“We don’t know much about this, but it’s going to end up killing somebody”
I’m not going out on a limb to say that this statement of Missouri Rep. Ward Frantz might be a bit hysterical at this point but I could be wrong. Human toxicology studies have not been done and the indole moiety of the drug dose raise the possibility that it may cause serotonin syndrome, a potentially fatal but relatively rare disorder. Otherwise, this concern is far overblown when compared with other drug issues in America’s heartland such as methamphetamine.

“Surprised it took this long”
It’s worth reading the backstory on Professor Huffman in this UK Guardian/The Observer article:

JWH-018 was “nothing special”, Dr Huffman remembered, “but it was one of the more potent compounds we made, and it was quite easy to make from commercially available materials. Probably the reason it has now caught on.” […]

[…]”My biggest surprise was that this all hadn’t happened sooner,” he told me. “All it needed was somebody with a reasonable understanding of science to see the papers we had published and think, ‘Aha!'”

And with the perspective of a 77-year-old organic chemist:

“I’ve lived around the world a long time,” said Dr Huffman. “I’ve come to the conclusion that if an enterprising person wants to find a new way to get high, they’re going to do it.”

JWH-018 is however already classified as illegal in several European and Scandinavian countries. So unless JWH-018 does something different from garden-variety marijuana, outlawing it in the US will just push folks back to God’s own herb.

Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, & Martin BR (2000). Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence, 60 (2), 133-40 PMID: 10940540

125 thoughts on “What’s the buzz?: Synthetic marijuana, K2, Spice, JWH-018

  1. i’ve only heard of this in recent months myself. if i may note, another factor in the effects of this stuff compared to marijuana is agonist efficacy. (for both immediate effect and adaptive response.) i’m not seeing anything about that on pubmed.

  2. I’ve heard that a study of JWH-015 indicated some chance of carcinogenicity, but I haven’t seen the study myself and don’t know how informative that would be about JWH-018 or JWH-073 in any case.
    One thing that definitely can be problematic, especially compared to cannabis, is dosage; an average dose of JWH-018 is only 2 or 3mg, and exceeding that can get uncomfortable in a hurry.
    As for effects, JWH-018 and JWH-073 are similar to cannabis, but definitely not identical. I suspect that most people would be able to tell the difference in a double-blind study, and most would probably prefer cannabis.

  3. I’m from the UK and work in the drugs field. Spice was made illegal here on the 23rd December but to be honest it has received very little interest and, as far as I am aware, very little uptake (both pre- and post- legislation). It’s quite expensive and cannabis is so widely available, the vast majority of people can easily get hold of it and prefer the real thing as opposed to some synthetic cannabinoid.
    A drug that has absolutely exploded in use over here in the last couple of months is Mephedrone (4MMC) which is currently legal but has had a huge impact on UK society. Is this drug appearing over in the US and other places? I am just amazed at how quickly it has become a huge craze over here.

    • I guess it’s a cultural thing. Mephedrone is like cocaine or something right? I’ve never heard of it on this end of the pond. Americans are huge pot smokers. And I mean huge. You can’t throw a stick without hitting someone who is either dealing or smoking. It’s decriminalized in a lot of states, not just California. In Mississippi, the only legislation about it is that you can’t smoke or possess marijuana within a certain few feet of a church or school.

      • Mephedrone is very likely a stimulant but we know very little about it at present. Some users say it is kinda like Ecstasy. Others say it is as good as cocaine when taken intranasally.

        structurally it has a core structure (cathinone) which is similar to amphetamine- however if you think about the way the 3,4-methylenedioxy modification of methamphetamine makes Ecstasy far different from Meth then you will be hesitant to get too confident about the pharmacology of 4-MMC/mephedrone.

  4. A drug that has absolutely exploded in use over here in the last couple of months is Mephedrone (4MMC) which is currently legal but has had a huge impact on UK society. Is this drug appearing over in the US and other places?

    It’s obtainable, but I don’t think it’s particularly widespread. Seems like most RCs are pretty much unknown in most areas.
    As for cost, that may be true of Spice, but pure JWH is much cheaper than cannabis per dose.

  5. Until employers and governments have widespread urine testing for this it will continue to be popular weather legal or not. Governments banning it raise awareness of it and also legitimize it as a substance that works at getting someone high.

    • A lot of herbs that used to be used for medicinal, hallucinogenic purposes. Lion’s tail for one. So, it’s a combination of the herbs and the chemicals sprayed on. They keep saying that the plants used could be toxic blah blah blah, but from what I’ve found, they have been used for medicines by witch doctors and stuff.

  6. The potential carcinogenicity of the JWH compounds centers around that naphthalene ring hanging off the side. The studies with JWH-015 showed that it was being metabolized via epoxidation in vitro, a pathway known to produce carcinogenic metabolites from many polycyclic aromatic hydrocarbons. There’s no in vivo data to indicate whether this pathway would be utilized or any studies on that particular metabolite to indicate whether it would actually be carcinogenic. This group, however, is shared by nearly all of the JWH compounds, including the most commonly found ones, JWH-018 and -073.
    There’s some speculation that JWH-081, which has an additional methoxy group hanging off the naphthalene ring, may avoid this risk since it would be open to more metabolic pathways besides epoxidation, but no actual studies to give any data one way or the other. JWH-250 has a 2′-methoxyphenyl group in place of the naphthalene ring, so epoxide formation is probably off the table, but given the complete lack of studies on how these compounds behave (beyond the non-blinded n=1 studies of their subjective effects), there’s no telling what other adverse effects they may or may not have.

  7. Thanks for the info, Ted. I’m curious to see more information about JWH-250 as research proceeds. I’ve seen JWH-200 and JWH-250 for sale, but I’ve heard essentially nothing about either in terms of health effects or recreational value.

  8. Druggies? Good ol’ beer and cigs? Are u serious? What do u think your good ol’ beer and cigs are? DRUGS… dangerous drugs that have killed millions of people! Just because they’re legal doesn’t make them safe! For your intelligence sake, I hope you’re referring specifically to not putting this new synthetic stuff, not real marajuana, into your system. Alcohol and cigarettes are scientifically proven to be FAR more dangerous and poisonous to the human body then marajuana… but we all knew that already right? Everyone has already known this for quite awhile and even taught their children this truth. Even before I became a bio-medical sciencetist, that was the general consensus of the public I was aware of.


  10. Nice work. Funnily enough I quoted that last line of Huffman’s from the Observer that you have in the piece at the med students today – they were discussing whether tobacco or cannabis smoking was worse for you, and why people would risk taking mind-altering substances (!).
    My 72 yr old mother worries about Alzheimer’s Disease. I’d better not tell her about that last weird ALL-CAPS comment or she may be stoned out of her gourd at the next family Christmas Dinner. I tend to try and persuade her that brisk walks and crossword puzzles are the best preventive.

  11. In my area, K2 popularity is spreading like wildfire. Many people are using it as an alternative to marijuana because K2 does not show up on drug tests, and everyone seems to be on probation nowadays.
    It’s a very interesting herb.

  12. I find it concerning that the ingredients listed on the package are all herbs or plant material with no mention of JWH-200 or JWH-250 or what’s been done to these ingredients. The funny thing is that when people buy weed from a dealer, rarely do they know where it came from or what’s been done to it so I’m not really sure how to justify my own concern about the label.

    • Sometimes they put on there “aromas” or some other random name for it. I think they are afraid to put it on there in plain site because it’s a chemical that really has no other use except to mimic weed. It’s sort of an underground knowledge that when you buy it, it’s for getting high.

    • And yeah. If a dealer ever says that your weed is better or special or enhanced, it’s laced with something. And most times, you have no way of knowing. The USA pays for pesticides to be sprayed on grow ops in South America and a lot of illnesses have occurred that way. I’ve never felt completely safe smoking weed because you really never know. With an established company that is selling something in a store, there is a paper trail where you can find out where it all came from and what was used (usually). Drug dealers don’t usually release their boss’s names or where the weed comes from.

  13. It may turn out that the wide spread interest in this synthetic pushes lawmakers to realize the demand for the real stuff and the opportunities to legalize and tax it to help our current economic problems. California may be voting on full legalization this year.

  14. Well, I’ve been giving this drug some thought & think it should stay legal. It has been around for years, & if it really was dangerous, we would’ve heard more than just rumors. Actually, I haven’t smoked any weed in years, but I think it should be legalized & alcohol made illegal. For real…what good comes from drinking? Have you ever heard of a Mothers Against High Drivers? & there’s a reason for that. & here in Texas, the drinking laws are stupid. My 19 year old daughter worked as a bartender & could ‘taste test’ the mixes, but couldn’t walk into a liquor store. So, she could sell it, but not be around it. Restaurants serve alcohol, knowing full well that when the customers leave, they’re gonna drive away-which is illegal. I hate these mixed-up laws.

  15. Listen,m im a heroin attic and on ua’s for parole and having somthing legal like k2, kind spice, black mamba, ect… is a great alternative for a drug attic. I know i would be back in prison if it wasent for JWH-018, its better than nothing, or using illegal drugs and blowing a hot ua. So i say keep it legal, its suposadly a free country anyway right? But thats a whole other subject.

  16. They will make k2 illegal. Why? Because it makes us feel good,that’s why. Nothing posted here will stop it, either. It’s ridiculous when you think about it. You can buy all the alcohol you want and get out on these roads and kill someone or yourself. How many guys you know smoke some weed or k2 and go home and beat up on their families. Now how many times have you heard of someone downing a bottle of something and doing just that? What else do they say? “Marijuana is a gateway drug.” Really? Gateway to what, my refrigerator? Cigarettes have killed millions upon millions of people in this country alone, and yet you can smoke all you want. My stepfather has been a paramedic for over 25 years and he tells me the number of dead people he has had to scrape off the road due to alcohol is enormous, but never has he had to deal with that because someone smoked a little pot and ran a family down. How many times have any of you smoked some pot, and woke up the next morning with someone you do not even know, and spent that whole day next to the toilet wishing you were dead, puking your brains out? How many times has alcohol been a major factor in someone cheating on a spouse? A lot! Ill quit ranting because as I said it will do no good. The United States will never legalize marijuana and will eventually make any thing like it illegal.

  17. For the fact that not everyone has the freedom to smoke the ganj pep spice/spice gold are great for people that want to get on that “level” and not risk going to jail for having to pee in a cup (and have THC show up positive in the drug screen!). Lawmakers are cracking down though so i suggest to those that are using pep spice/ spice gold stock up while you can lol. I personally have used pep spice because i had a job interview coming up and i knew they were gonna piss test me so this was cool to use until after the test. most places ive found are kinda pricey, http://www.dieselspice.com has it this stuff for pretty cheap, anyone tried ordering from there?

  18. Orange Crescent is the best Herbal Incense on the market!
    It contains no toxic additives. Half the price of the big names and twice the quality.

  19. I personally dislike cannabinoids so I haven’t investigated sourcing this product.
    But, hypothetically, if I were interested in a product that was about to be scheduled, I’d investigate overseas sources. China, Taiwan. It’s not difficult. Make sure you get ask for, and receive beforehand a CA (Certificate of Analysis).
    I haven’t looked up the patent on this stuff, so I don’t know the degree of difficulty or the equipment required to synth, but I’d wager 99%+ of the stuff is coming in from one of the major chem manufacturing countries, and then people are lacing whatever combustable herbs are easy on the throat & lungs- rather than someone bothering to labor over their own labware to synth.
    This is the way it was done with most other synthetic psychotropics before they went scheduled (sometimes after…). Pallets of 55gallon drum barrels of GBL,big barrels of BZP & the other phenethylamines. It’s almost always cheaper & easier to import when it’s legal. You can look at domestic sources like Sigma & Fisher (In USA)- but they’re seldom good for quantity of anything other than staple products (good for ref samples though). Most of the suppliers of “pure” k2/k3/mephedrone claiming to be domestic are undoubtedly just repackaging Asian sourced product judging by their prices.
    Look to the east for true wisdom, Grasshoppas. Many hidden treasures.

  20. ay personaly fuck spice that shit aint good for you after i had the worst high ever throwing up worst headach and supposebly it can kill u na i gonna take another chance ppl jus stick with maryjane but i aint saying dnt use it it really helps for them ppl who on probation.

  21. I’m with you on this one, wtf! Yes I smoked the real thing, which I got in trouble for it. but, I’m not a freakin’ druggie! I was in an EF4 tornado on this very day in 2006. I was airlifted to the Springfield, Mo, At St. John’s Mercy Trauma center & I was slipping further away from my family. Anyway, after being at St. John’s trauma center I finally got home. Well… my family dr put me on Methadone, since I had been on the duragesic patches after being released from the hospital. But, I couldn’t funtion! I have 2 boys, 13 & 11, they know that I smoked it. And, yes, I know it’s illegal, but, I needed something more, kinda like a supplement. To reduce the pain that was my only option.I’ll fill you in on what all that Tornado did to me…
    *Broke both of my collar bones (had surgery on 1 of em)
    *Broke all the ribs on my left side
    *Collapsed both lungs
    *Crushed my back in 3 places
    *Had a compound fracture(I think that’s what it’s called anyway)… The lower leg bone was sticking out of my leg.
    *I have Titanium from my neck down to my ankle
    I’m not Cheech & Chong, but, it helped me with not only my pain, but my anxiety as well. (PTSD thanks to that twister). Like I said, I got in trouble for possession. But, I went & saw my Probation Officer y-day & she’s the one who told me to look this up & YOU DON’T KNOW ME! I would gladly, in less than a heartbeat, trade this titanium filled body ANY DAY! Well, no I wouldn’t ’cause I wouldn’t wish this on anyone. But, please do as the Good Book says ‘Judge not that ye be not judge. For by what judgment you judge, you shall be judged. My PROBATION OFFICER told me to look this up to help with my pain. So, if you don’t like what you’re reading… maybe you should just go to a different page! JMO *TOTALLY & COMPLETELY DISABLED STARTING AT THE AGE OF 33* But, sometimes that’s the only thing that can relieve a panic/anxiety attack. I don’t
    mean to come down on anyone, but, Catergorizing is the same as Judging. If she thinks the ones that look at this are druggies… Wasn’t she on her looking at it too, that’s how she posted a comment???? Hmmmm….

  22. This site is the best site to use…
    I have had so much success buying and then reselling from this site because the purity is so high.
    I think that anyone who is interested in this stuff should definately go checkout this site.
    They are based out of dallas and are definately reputable… They even do in person transactions for people local to dallas, texas…
    which is AWESOME for people that are sketched out by the post office.
    all though the first couple times I did buy from them online I got my tracking numbers the same day and got my shipment the next day and the other one on the third day since I didnt order enough to get free overnight. http://buyjwh018online.com

  23. Tried concentrated powder – not the sprayed vegetation stuff.
    It is shocking how LITTLE you need of this powder to get way high. The old adage about MJ is that “you can’t overdose” because you only get to a certain high and go no further – maybe fall asleep. With jwh-018 – you easily can take too much and get too high and really have a horrible time. Not because you are “too high” but because you feel like total crap and are simultaneously scared (at least that happened to me – a very experienced MJ partaker in years past).
    BE VERY CAREFUL is all I have to say.

  24. i used to be a pothead until my parents caught me, and now they drug test me every month so i can’t smoke weed. ive been smoking k2 for about a month and i am shocked at how high it gets me…its almost scary. if you can’t smoke weed k2 is the closest you can get, it makes you trip alot harder though and can be scary sometimes. it tastes good and dosent make you cough. when you come down you get extremely tired but you don’t feel in a bad mood like when you come down from weed. my friends who smoke weed still sometimes ask me if they can smoke it with me because its so intense, one bowl is like smoking a blunt to the face. it dosent last as long, but its really fun while your high. i kinda get the spins from it if i smoke too much and it can be uncomfortable but that usually goes away within 20 minutes or so.

  25. K2 Usage

  26. ive had to stop smoking weed lately(testing) and i have to agree that this is the next best thing. its not as good as week, but for people who like to get fucked up, i suggest it. i would not smoke to much at one time though because last weekend my friend had about 2 grams of it through 6 bowls and had to go to the hospital because his heart stopped or something. if you have the choice, choose weed, but this is ok too

  27. if they would just legalize cannabis, then people wouldn’t be resulting to using synthetic chemicals to get high. marijuana is much safer, it has been studied for years now. i do not understand why this country sales alcohol and tobacco(both of which can kill people and are highly addictive)LEGALLY, but chooses to discriminate against people who smoke it. this plant that god gave us has so many good things about it. you can use it for fuel, paper, housing, textiles, food, oil, killing cancer cells, pain relief, anti anxiety, and most of all inspiration. there are so many musicians that have used it to come up with classic masterpieces. also i don’t know if everyone remembers a young man that won 8 gold medals in the Olympics just real recently, but marijuana most definitely did not get in his way of becoming a great athlete. now… that all being put aside and marking it out and forgot about… just imagine how a tax on the plant could help boost the economy. just imagine no more people being killed over the product and people being locked up for such a petty “crime”. so in conclusion, as long as America keeps this wonderful and harmless plant illegal, people will continue to search for new and unsafe substitutes, and the war on drugs will continue, people will be killed, and locked away and the economy will continue to crumble.

  28. There have been a lot more states cracking down recently. I really enjoyed the availability of herbal incense as a legal alternative. Everyone just wants to be left alone with their favorite JWH compound without having to break the law.

  29. As both a user of marijuana, as well as having much experience in experimenting with a few forms of the JWH compounds, I agree with a lot of what has been said by the board. Looking for the alternative substance is what powered my first search for the analogue. I can see why you would prefer the JWH over pot, as far as potency, duration of effects, and the aestheticness of the high. I found that JWH-018 is sometimes accompanied by an overwhelming sense of anxiety, but that is with higher doses that weren’t properly measured. Overdosing is pretty horrible as well; Usually totally consciencious of your surrounding with an unensatiable desire to vomit for long periods of time; avg. 25 – 80 minutes; regardless of stomach contents, an empty stomach will result in dry heaving and acidic spit up. But that’s why dosages should be measured. As far as the “fake weed” goes, I’ve tried ‘Biohazard’ and it seems to be one of the more potent herbal supplements out there, but pricy, $45.99 for 3 grams. In conclusion, while marijuana is illegal, people are always going to be looking for other ways to get high or just smoke pot anyway. Really seems that once of the best proposed resolutions is to tax and maintain government regulations over it. It worked for alcohol and tobacco products, only makes sense that it would work in this situation as well.

  30. Hey Guys , What is the “synthetic cannabinoid” ? So, it means synthetic cannabinoid=marijuana ? there are a lot of packs(bonzai, jamaican gold, dream). There is synthetic cannabinoid in these packs, isn’t it ? What is the difference between synthetic cannabinoid – marijuana ? Police dogs do not understand the smell of cannabinoid ?

    • Basically it’s like sweet and low vs. cane sugar. Same taste (almost) but different nutritional value. Considering that it is technically legal as of today, drug dogs can’t sniff it out. If you don’t want to get caught with weed or the fake stuff, youtube “Never get busted again.” The synthetic versions being sold are herbal mixes that is sprayed down with a lab made molecule that do the same shit in your brain that the molecules made by nature do. You can tweak the molecule a million different ways (kind of) and it will effect the brain the same way or very close to the way weed effects your brain.

  31. I have a few questions, I have just heard of this and according to its packaging it is herbs. What herbs ? what is the mix ? is it a secret? they say its not to be smoked ? yet I see and have read here that others do this. and of course we all know everything government cant and does not control is dangerous, and of course the government wants his share of everything.and what is the K-2 everyone is speaking of? I typed in the company name and looked for the ingredients, but even the site wont tell you. so I come here to ask you.

    • On some they list the specific ingredients (except for the actual chemical that gets you high). It lists: Damiana, Lion’s Tail, Mullein, Lemon Balm, Mint, Passion Flower, Aromatics is in Green Spice. The one I just bough, Fusion, has Damiana, Mullein, Motherwort, Mugwort and Bay Bean Extract. The new blend they are pushing out after the 24th when it all becomes illegal has Damiana, Dandelion lead, Wild Dagga, Hops, Mullien, Lobelia, and whatever aroma like mint or mango. You can go to Erowid.org and look them up. Some of them do in fact have hallucinogenic effects and some of them can cause illness, although I am convinced that most of the negative reports are panic attacks as I have had two, one on weed and one on synthetic and it pretty much mirrors what a lot of people are posting as a bad trip.

  32. So a buddy of mine ordered a gram of jwh-018 and this stuff is ridiculous. Between 5 of us we went through about 400mg in an evening… you do the math. We started by just trying spice, and when it worked we moved up to just the compound. A little sprinkle added to the tip of a cigarette makes it like a personal joint. I highly recommend jwh but be careful, im sure overdosing is possible as others have said but none of us had any ill effects… just great times. Get it while its still legal.

  33. i’m afraid you are severely mistaken dude. There is almost no way that you consumed about 80mg each over the course of several hours especially without any ill side effects. Only somewhat reasonable rationale would be that you have been consistently doing jwh daily over the course of a few months and have developed a ridiculous tolerance to the product, which is still unlikely. Between 20 – 30mg you are for lack of a better word, incredibly f-ed up even over several hours. At 80mg you might be looking at a heart attack or something worse. So you do the math, numbers are too big broham.

  34. I will tell you all right now, you can overdose on jwh very easily. The “spice” being sold over the counter in sealed containers is relatively safe, if used in moderation, but there are always going to be entrepreneurs out there hoping to capitalize on this new product/drug, especially now while it is still legal. And why not? An ambitious person can make
    as much or more then a drug dealer and not have to worry about legal issues. But beware. the people that are making it can make it any level of potency they like, simply by spraying a little more,or less of the mixture onto the herbs. I smoked weed for thirty years, and never got sick or overdosed on it. But recently, I started smoking spice as an alternative to weed mainly because it was easily available and I didn’t have to worry about getting arrested.
    On a recent trip to the town smoke shop for some spice, the owner reached under the counter and produced a small zip-lock with about 1/2 gram of spice in it and gave it to me, to sample. That night, after taking three hits of this sample, was the worst i have ever felt in my life. I had to crawl from my computer to the bathroom, where I proceeded to vomit off and on for 2-3 hours. My whole body was shaking,cold sweats,irregular heart beat,blurred vision, equilibrium completely impaired. I couldn’t stand up, no matter how hard I tried. After laying in the bathroom for about three hours, I was able to get to my bed and fall asleep. The next day, I threw the rest of the sample in the trash. I am in no way, a lightweight, when it comes to getting high. all through the 70s, 80s, and 90s, I indulged in excessive use of weed, alcohol, cocaine, meth, lsd, dust, pills, and anything else you could possibly imagine, and have never experienced anything like this. So, like I said, BEWARE. You never know what your buddy, or the local spice dealer has concocted. I would suggest that if you are going to use it, buy the spice that is manufactured with a brand name and is sealed. It could be the difference between life and death

  35. If I had enough money to buy a few grams of spice, and I couldn’t get any cannabis – I’d just hitch-hike to california, rent a hotel for a weekend (with the money for a few Gs of spice) and get some free kindbud from the locals. Seems like a much easier way to get high. But I guess some people are just too attached to the cows, cornfields, and meth-labs of the “heartland.” LOL

  36. i’ll still stick to smoking something natural, why mess around with synthetics when we have a natural product. idiotic masses, thats why

  37. K2 has helped with my pain and nausea caused by Chrons AND my friend going through Cancer treatments. Their are others like spice or black momba THAT IS NOT MADE THE SAME NOR IS RELATED TO K2. Test it! K2 is a blend of flowers and herbs and the JWH chem that is in it is also in the pain meds my doctor gave me. K2 works better than the pills for me and it doesn’t make you stoned stupid. I can get up and clean house instead of lay down and fight pain. Worried about what you put in your body? Really?? Look at your food labels. You are eating chemicals that are poison and toxic to your body everyday. K2 DOES NOT make you hallucinate. I wish pot wouldn’t wind me up in jail but until it’s legal I’ll keep the K2…lets hope they don’t outlaw it now also. Buy the way, it is made in the USA.

    • I didn’t know it was a chemical also used in pain meds. That’s pretty cool. The point of making synthetic weed was primarily to find a way to stick it in a capsule and give it to patients. Loophole. They are outlawing Spice blends on the 24th of this December, but they have already ordered new blends that aren’t included in the DEA’s little ruling. I don’t know how good it is, but I’d get a baby sitter and try it out.

    • I think it’s the flavorings they use in K-2 and some more mainstream spices. Just don’t use K-2. It’s pretty much shitty from what I’ve heard from everyone that’s smoked it and it’s being counterfeited like crazy.

  38. i smoked this stuff the other day. i thought it was just weed. a had never smoked anything in my life so this really messed me up. i had no idea what i got myself into. i took 5 deep hits and shortly after that i started to feel it. my vision was flashing from black to picture then black then it would go back to the picture but the person was somewhere else. i was freaking out. my eyes started to roll back in my head and seemed to vibrate. The cops then showed up because they got a call. I had no idea it was legal and that it wasnt weed so i was freaking out. i went back to my friends house. i couldnt walk anywhere by myself. I was constantly twitching and jumpy then sleepy. My high lasted for about 3 and a half hours. This stuff is no joke. my nostrils seemed to start closing and my lungs were tight. i could smell it on my breath into the next day. my hands are randomly twitching now and i cant breath normally. i wish i had known better before i got myself into this mess.

    • It sounds like you had a panic attack. I’ve never had a bad trip until I took some fake weed. It’s a much more delicate drug that you have to be really careful with. Small small doses. Two hits on a pipe or a joint is too many. Severe panic attacks can also lead to vomiting, which, if you didn’t know that, makes the paranoia and panic set in even worse, making you think you were poisoned. A lot of drugs that are completely safe so far goes as toxicity if you take them in the right doses, but can lead you on a terrible trip if you are in the wrong mind set or are nervous about it or are like me reading all about deaths related (or completely unrelated) to spice while you are high. I have an intense fear of spiders and that for me is what set off a panic attack when one crawled on my bed after I smoked some spice. I felt paralyzed, afraid to get off the bed, afraid to stay on the bed, my room was messy so I started imagining spiders hiding in my laundry and in the carpet and eventually I had myself believing that they were there. Scariest shit of my life. But I would have had the same reaction if I had smoked weed too. So if anyone out there has felt the way this person described, for future reference, that’s what a panic attack feels like when you get too high.

  39. I just got some awesome Incense online. bought a sample pack with 5 flavors. Halfbakedincense.com. I love this stuff. Being on probation its a savior. I was a marijuana user and this is a great alternative. I recommend this site, the flavors were great!!!And bags are 3.5G 🙂

  40. I have been smoking spice for more than one year now, the problem is that it is not consistant. I have smoked spice that is amazing and some that plain sucks. Finally, I decided to make my own batch. Yep!!! So I bought 1 gram and turned it into 50 grams of spice and the quality is the best I’ve had. Buying the pure JWH-018 is the key, I bought mine from mountainindustry.com. They seem to have the best stuff. Anyway, once you make your own, you will never buy spice again. Trust me. Use coupon code L27MHJ1

  41. Wonderful stuff at just the right levels it feels just like pot, get too high and think your gonna die just go to sleep and feel better when you get up, seems identical to me, I get the munches too.
    Better to regulate than prohibit, prohibition has never worked and never will, the war on drugs is a financial failure that even the gret Obama can’t tackle and what gives any human the right to extinct plants from the Earth that God has put here?
    People wake up, our government has gone too far, they extinct plants, take people’s firearms when the need them most, like after Katrina, they invade our homes to “inspect” them using an “Administrative Warrant” and then charge us with criminal conduct if our home doesn’t meet their standards, they tell women that they must bear children if they get pregnant, when will it change!

  42. Ive been smokn spices now for like 2 months and ive had no problems. There is an ingrediant in there that makes you poop, I dont know which, but i dont care as long as i feel high im all good.. I do have a pretty nasty cough from it though! Never smoked the straight compound, atleast i dont think i have.. Wats w the mg talk? I thought this funk is sold by the gram? Sprinkles? Sounds like shiva crystals.. FaKe OuT SeSSioN..

  43. Well, I haven’t been smoking it long, but tried quite a few, from websites, ebay, ioffer, ebid, etc. and I can tell you that the only one I would buy is wildfire. I discovered it by accident really, got one and wow, I was sold on it right away. What I liked about it was the scent, the herbs, and what it does for me. I really just cannot say enough about it. If you are interested in checking it out, just go to wildfireincense.com or just google it. It isn’t out there much, but you can get it. I tried black magic, mystic, K2 (which I thought was crap), Spice (the same as K2), and many others, but wildfire incense blend was the one that did it for me.
    See, thing is, I hadn’t smoked anything in 30 years or more due to licenses or jobs, so when I found this, I was extatic now that I can actually smoke again and safely too. Well as long as I get it in a legal state anyway.
    I could go on and on about it, but it really pisses me off, that now that I found it, they are trying to make it illigal now too, know what I mean?

  44. k2 summitt has some competition now called Sense Incense VERY POTENT stuff man! atleast to me they are on ebay and its $10.00 3g!! very cheap comparing the two . Just the friendly heads UP

  45. Legalize Cannabis dammit, tax it trust me goverment you’ll make your money, its much less dangerous than alcohol, or other hard drugs so wtf, were in a depression but we are using millions of dollars putting people in prisons for cannabis, when that money could be used resoucefully to help out this depression where stuck in cause of this nonsense, we just want to get high??? Maybe Cannabis will save the Nation ???? Im a beliver everyone else should stick to this theory, and lets live with the freedome of just wanting to get high????

  46. Part of an article from Hastings Star Gazette, Hastings, MN, US.
    Synthetic marijuana nearly claims life of Hastings teen
    Stacy Huberty was scared, really scared when her 14-year-old son overdosed recently. Then she got mad. The “drug” he overdosed on, a new “synthetic marijuana,” she found out, and is sold legally. Her son, she said, is having enough trouble staying straight, staying off the real thing…
    The story goes on and ends with, “We talked about it (the Spice he smoked),” Stacy said. “He said it was the most horrible thing he’d ever smoked. He said he felt like he could feel the blood moving through his arms, chest and neck, and he thought he was going to die.”

    • Ok. I have smoked real pot for years, never ever had an issue. We recently moved and have no connects here so my bf has been getting the fake weed…I tried some and it DOES make you feel like you’re dying…I am actually glad to have found this page cause my bf keeps telling me its just in my head. It gives you the strong feeling of mortality and death and makes it harf to swallow.

    • No. It has no alcohol in it that we know of. There aren’t any drug tests that can tell if you have it in your system that I know of. It would be hard to determine in that woman’s autopsy if she had smoked it recently I think. But, you should be safe. Be careful when you use it, only smoke maybe a pinch of it. Take it one hit at a time and research about panic attacks so you know if you are having one. Get a baby sitter for your first time if you haven’t smoked it.

  47. This stuff is great! I have had dumb ass friends OD on it though. If you mix it with weed, the effect is amazing. Driving is really fun while on it. 98% of the time I am high, I am driving.

    • It is a beautiful thing to use while driving. Especially through the country side. And before people bash stoned drivers, there was a study that came out that said people under the influence of cannabis drove consistently a few miles below the speed limit, increased following distance to a safer level (how many of you guys really follow the two second rule sober) and were more focused because of the paranoia and extra caution taken by people when they use weed. I don’t think you can OD on it like you can other drugs. I think a lot of kids are just getting too high. A lot of people expect it to be exactly like weed, but it’s different, so it can be scary if you don’t know what to expect. Panic attacks are more common with it.

  48. I, Myself smoke jwh-018, jwh-250, jwh-081. I could tell you, that all of these chemicals, have not had a negative impact on my health as far as I can tell. I’ve made homemade spice with these chems, right now, I have an RC, that sells all 3 of the above mentioned chemicals. 25$ a gram. And you could make 2 ounces. of jwh-chronic. I once made, a batch that had 1g of jwh-018 and a quater ounce of damania leaf. It was like space-spice for real. if anyone would like to more of have any questions just e-mail me… tata!

  49. All i gotta say is shit stop complsainin bout it and writing ur life out talkin bout carcinagens and affect!!! you are smoking it WTF do you expect… and to be honest K2 or legal bud is way more potent than the good ole Mary Jane yet it doesnt posses the potency of some good dro or hydroponic shit. but im sick of people makin it out to be bad and is gonna kill you………. ANYTHING YOU SMOKE (for long enough) will KILL you

  50. my friend smoked that stuff and got real sick and was freaking out. He had seizures and eveything couldnt remember who he was or where he was at. he smoked with our other friend and he too couldt remember anything and was sick too. They both ended up in the hospital that night and one of them almost died. that stuff is stupid and can kill you!!

    • This drug does have serious side effects if you are given a badly mixed batch. My brother almost died last week after consuming a few hits of “spice”. I am not a drug user… do not see the point. But I will agree with Amanda… do not be naive to assume there are no negative side effects while using this drug. Everyone does not react the same to the drug, so while you might have gotten a nice “high” off of a few hits, it is very possible for someone else to OD. People have died because of Spice use… it can happen, it has happened and it will continue to happen whether you choose to believe so or not.

  51. where do I find k-2 fake weed. My sister lives in Texas and has a prescription from Maine for real weed.Her new doctor in Texas has her trying k-2 for they do not honor her prescription. I am in Florida and my boyfriend smokes daily the real stuff where do I find it. my sister loves it.HELP

    • Texas has plenty of good weed due to I-10 running through as a major drug high way. She could probably find something pretty good if she doesn’t want to take the risk of using synthetic. But, head shops are the best place to go. They are having blow out sales (3g for <20) and the guy I talked to today said that after prohibition kicks in they have a new blend to sell, so keep a look out. I got a free sample today, but I haven't tried it. Going to do more research. Her doctor is fucking awesome.

  52. hey amanda,
    people that almost die make it into the news. post a link to the article about it so we know you’re telling the truth. know why you can’t? cuz you’re a liar like D said, and cussing him out doesn’t help your case either.

  53. wtf dude. For one people o.d on shit all the time and they dont make no paper or news. I woudnt waste my time writing a link nor would i even know. I got a lil mislead on this shit and wanted to research it. i made a lil opinion/example. And what case? Wanted to throw my story out there, I dont appreciate being called a liar!

    • I believe that they had a bad experience, but I don’t think they were at risk of dying. A lot of these calls into poison control are more likely panic attacks which are pretty horrifying and have symptoms not normally thought of when you think of having one. Nausea, tremors, vomiting, increased heart rate, extreme fear (feeling like you are dying), feelings of paralysis (not generally true paralysis, but you feel like you can’t move), constricting of the throat, difficulty breathing, trouble swallowing, fainting, chest pain (why people think they are having a heart attack after smoking the stuff), cramping, etc. All of them are symptoms of a panic attack which can mimic what you think you might feel if you were being poisoned. I also suspect that there may be allergic reactions to the stuff because most of the herbs used aren’t something you come in contact with regularly and aren’t usually tested for in the doctor’s office, so you wouldn’t know until you tried it.

  54. I’ve personally been smoking “spice” for months, and i am very pleased with it. When i first started, i was buying pep-spice. and managed to spend $1500 in one month at my local headshop. Obviously, i needed a cheaper way. so i researched it, and found a recipe that works very well, and here it is:
    1 – Dissolve 1 gram pure jhw-018 into 400mL of strong liquor (it is NOT water soluble, but is liquor soluble like marijuana (i use 160 proof vodka))
    2 – add the solution to 4-5 ounces of a smoking herb blend. (i mix damiana and marshmallow leaf)
    3 – Let dry for 4-8 hours (adding a fan helps)
    The places i order from, i spend roughly $15 to make 1 ounce. The herbs are cheap. $5-20 per pound. The liquor will run (based on size) $15-$30. The JWH (on the expensive side) is $60 a gram. That 1 gram, will make 4-5 ounces (based on how strong you want it).
    Mixing too strong a batch (or even using the powder straight) is DANGEROUS. Too much of JWH-018 can incite a panic attack (for the guy who mentioned trying the powder and being scared). i dont have the research that shows this on-hand, however you’re on the interwebs, im sure you can find it.
    Also, i suggest a bong or water pipe. The herbs can get harsh (much more so then marijuana).

  55. ok, so, i make my own herbal blends, and i usually put my JWHxxx or WIN 55 on tea that you buy at the store but i dose it really heavy I use 0.75g to an oz of tea, my customers are happy as shit and there have been no problems, what you guys are failing to see is that this is NOT thc, and should not be treated the same way, it hasn’t been around long enough for there to be known long term side effects. but there is alot of research showing alot of positives about certain JWH types, i cant remember which one exactly, but it’s showing very positive results in studies on the effects on alhtzhimer’s.
    second, do not use it with a bong or water pipe. JWH has a tendancy to resolidify on the coldest surface / substance it comes in contact with. so when you rip your bong your losing quite a bit.
    also it’s better to vaporize it, if i remember correctly, it doesn’t combust, or it loses it’s effectiveness once combusted.
    so if you wanna do this shit right, go grab a light bulb or some tinfoil and do ‘er up that way, that’s why i refer to it as “weedcrack” (i guess a vaporizer would work too). if you use a vaporizor, it vapes about 20 degrees hotter than doja.
    don’t waste your time snorting it, it don’t work.

  56. DRUGS… dangerous drugs that have killed millions of people! Druggies? Good ol’ beer and cigs? Are u serious? What do u think your good ol’ beer and cigs are?Just because they’re legal doesn’t make them safe! For your intelligence sake, I hope you’re referring specifically to not putting this new synthetic stuff, not real marajuana, into your system. Alcohol and cigarettes are scientifically proven to be FAR more dangerous and poisonous to the human body then marajuana… but we already knew that already right? Everyone has already known this for quite awhile and even taught their children the truth. Even before I became a bio-medical sciencetist, that was the general consensus of the public that I was aware of.

  57. There is a lot of counterfeit k2 out there and I wouldn’t be surprised if that is the cause of some of these bad experiences. Of course, tolerance comes into play as well. Some people can’t handle their booze. Hell, I get jittery off a few sips of harmless coffee….

  58. We have been offering high quality, high potency WildFire Incense Blends for awhile now and have decided to release a scary potent blend called WildFire Extreme, available in Mango, Strawberry and Cherry.
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  59. I cant see myself smoking this K-2 or this other product Blackmagic. It just doesnt seem right for some reason. i mean cost is definitely great but the concept of smoking incense or spice just sounds awful. im open to the concept and making this illegal is probably stupider than the already illegal marijuana but i just cant see myself doing it.

  60. Me and my girl smoke about 2-3 joints of k2 spice everyday.We’ve tried sonic,spush,;blazed and regular k2 spice.I think spush is the best I’ve had its 10$ at shells gas station.So far we haven’t had any thing weird happen or any bad side affects yet hopefully we wont cuz so far its been a potheads dream. Alcoholics can legaly have their alcohol, so why can’t us smokers legaly have the same right?

  61. A person should be able to stick anything or do anything to ones body as they feel if not directly causing any damage to anyone else. its not only our right. IT OUR BODY! If I wanted to shoot up heroin,crack,and paint thinner up my arm no one has a right to tell me I can’t. It’s ridiculous how bills and laws are passed because it goes against some peoples opinionated beliefs.

  62. Watch out for this stuff !! I tried some other incense/spice and everything was good. I don’t know if it was too much or not applied correctly but I OD’ed on this. I’m talking LSD style buzz. Bad experience and I’ve been around. I want to warn everyone! I am not an amateur and this experience was BAD. Try very little amounts of other items, but steer clear of K2.

  63. I have been a daily pot smoker for the last year or so and when I heard about K2 spice I decided to give it a try because I don’t like that Pot is illegal and I could lose my job over it. First time I smoked a very small amount of the K2 Blonde and I got mellow high with the exception being I noticed that during my high (1 1/2 hours or so) I kept having reoccurring thoughts of hurting myself.
    A couple days later I smoked a bowl of K2 Blonde. I was on my computer and within an hour I had the overwhelming urge to vomit, I couldn’t even make it out of my chair and vomited on the floor in my room, then stumbled to the bathroom where I lost it on the floor again. I was vomiting for about 30 minutes when I got a moment of clarity, I got to my feet and looked in the mirror after drinking some water and my pupils literally were the size of eye. It was totally freaky and I flushed my K2 that moment then fell asleep on the bathroom floor.
    Nothing at all like Pot. I’ve smoked pot till I passed out and never felt like throwing up, never wanted to hurt myself. Marijuana is peaceful, K2 spice is not.

    • K2, Spice and all that synthetic crap is nothing like real marijuana. Marijuana doesn’t cause ppl to have panic attacks, rapid heart rates and high blood pressure but K2 does. One cannot overdose on Marijuana because it is not a drug but a plant. K2 on the other hand is a man-made drug and those who abuse it are gambling with their lives!

      • Dude you’re dumb. Marijuana does cause panic attacks, rapid heart rate and high blood pressure. I would know, I’ve been smoking daily for half a decade.

  64. Pingback: K2 Spice associated with death of young Indiana mother of two « Terra Sigillata

  65. what people dont know is its not the JHW-018 or any other components its the ingredients used to make the flavoring. Try the non-flavored brands like Green/Red Dragon and Ace of Spades(most states sell this in flavors but online orders can be requested of non flavors). Been at it since it was introduced in another country and never had a problem yet!

  66. i would first like to say i like fah-Q haha…..my sister smoked that crack headed stuff the other day nd when she smokes it she thinks shes guna die i dont know why but when i smoke it i get stoneed for like 10 mins. then i got a headace nd shi* ya dig,, if anyone can digg anything im saying buy u a bag of kush u wont wana smoke no spice ya kno… dude says he spent over a thousond in a week on fake shi* thats crazy get the real deal playa and stay stoned all dayy… if weed aint legal in the next year or two in ohio im gunaa flip who wants to cheef a fat bong of spice if u got some flame dro or kush!!!!

  67. In houston TX most of the “fake” weed has been banned.. you might get them in a smoke shop under the table but obviously much more expensive… Supposely it comes out on drug tests as “pills” not sure what kind.. I heard this stuff messes with your head..

  68. i’ve seen these ‘legal substitutes’ change people–really good friends of mine– into fiend-ing crackhead-like shadows of the people i loved. they started smokin’ em just to pass drug tests to get employed. landing a job is hard these days and the longer they waited, the more they smoked that awful stuff. they got to pawning sh!! that wasn’t theirs, scrapping metal they jacked from other peoples yards, begging me to pay for their new addiction all the time, and stealing it from each other. they had their heads so far up Spice’s arse that they really couldn’t see how not like themselves they had become. i smoked it a couple times with them but had massive paranoid freakouts both times and just stuck to my weed since i wasn’t in need of having clean pee for any kind of drug test… they both eventually had a couple of really bad trips on the stuff– hallucinations of demons, they said, but by that point i really didn’t give a sh!! what they had to say about their ‘legal crack’– and they stopped cold turkey. i am still sad for them, for how this crap was marketed to them, and how it takes advantage of so many unsuspecting people who just want a good time so some douchenozzles can fill their pockets with the profits–marketed like it’s something that’s okay and perfectly socially acceptable because it’s not, it’s not, it’s not! if you have a head on your shoulders to know that this isn’t what a good time feels like then tell people. this stuff is not cool.

  69. Hey guys i’m from germany near oft munich, the spice sales in the shops are banned since one year or so, there was a very big Hype in my hometown, 20k people not many teens. But most of my friends stopped smoking weed because it was simply just hard to get for about half a year. Many turkish people packed it up by themselves and sold it… So somehow for about a year even when the weed was back in the City again there where like only 10 people who wanted some… Spice is fu*kin your head up More than weed, a friend of mine who smoked about 6 Grams a day jumped from a bridge and arrived 30 meters above on the stone ground.. I smoked a normal joint wih him a couple of days before and he told me the reason he was smokin so much is because weed is not getting him high anymore and from 3 bowls of spice he still picked us up in his car… This stuff is fuc##in u up so badly, im so happy i stayed only with Mary …

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